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  • Дорогие коллеги, читатели журнала «Экспериментальная и клиническая гастроэнтерология»!
    Журнал «Экспериментальная и клиническая гастроэнтерология» насчитывает более чем 25-летнюю историю издания.





    Ответственные за выпуск редакторы.

    Главный редактор ЭиКГ, Президент Научного
    общества гастроэнтерологов России, Вице-
    президент Российского научного медицинского
    общества терапевтов, профессор
    Л. Б. Лазебник  
    1. Clinical Hospital № 122 them L. G. Sokolova, St. Petersburg, Russia
    2. SPb St. Mary Magdalene Children’s City Hospital № 2, St. Petersburg, Russia
    3. St. Petersburg State Pediatric Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia
    4. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    Keywords: food hypersensitivity, diet, an individual diet, ulcerative colitis, inflammatory bowel disease, the methods of selection of the diet for ulcerative colitis, prevention of exacerbations of ulcerative colitis

    Abstract: Allergic reactions to foods can occur in any one of four major types of reactions [P. Gell, R. Coombs].The most typical combination of several types of reactions, one patient. Food antigens can modify cellular and humoral immune response by influencing the emergence of new and for chronic diseases. Objective: to study the spectrum of food sensitization in patients with diseases of the digestive system (DDS) to adjust their dietary therapy. The laboratory examination and treatment of 210 patient: 185 patients with DDS (gastroesophageal reflux disease, chronic gastroduodenitis, biliary dyskinesia, irritable bowel syndrome, IBD (ulcerative colitis(UC) and Crohn’s disease) and 25 healthy adults. To identify the reactions I, III and IY-type food allergens used a range of methods - ELISA (IgE-specific) and the reaction of inhibition of migration of leukocytes (RIML), modification NN Matyshevoy and LS Kositsky. Products that implement positive reactions, patients were excluded from the diet. 100% of patients identified specific reactions I, III and IY-type food allergy, the number of responses increased in proportion to the severity of the disease, most patients with IBD, the smallest - in healthy individuals. Exclusion from the diet of the identified potential allergens contributed to a significant clinical improvement, and in patients with UC onset of persistent clinical and endoscopic remission. Conclusion: to determine the most complete range of food sensitization in patients with DDS is necessary to use methods for assessing cellular and humoral sensitization types together. Diet exclusion of food allergens from the diet of patients with DDS leads to persistent clinical improvement and long-term maintenance of remission, especially in patients with UC.

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    Full text is published :
    Kryukova O. A., Matysheva N. N., Drygin A. N., Khavkin A. I. Food sensitization in patients with diseases of the digestive system. Experimental and Clinical Gastroenterology. 2019;163(3): 4–9. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-4-9
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    1. V. A. Nasonova Research Institute of Rheumatology, 115522 Moscow, Russia

    Keywords: dysbiosis of the upper digestive tract; rheumatoid arthritis; microbiome; periodontitis

    Abstract: Currently an increasing attention in rheumatology is paid to the identification of diseases at the earliest possible time, the so-called preclinical stages, which may contribute to a more favorable response to therapy and improved prognosis. The etiology of rheumatoid arthritis (RA) is still unknown. One of the possible factors of its development can be periodontal disease (PD) associated with oral dysbiosis. This review examines the relationship between the development of periodontitis and RA, discusses the involvement of the oral microbiome in the common mechanisms of the pathogenesis of PD and RA. Identified cell-mediated mechanisms that cause chronic inflammation and lead to bone resorption and destruction of the joints. The role of PD and P.gingivalis in the process of disruption of autoantigens citrullination is described.

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    Full text is published :
    Gordeev A. V., Galushko E. A., Savushkina N. M. Dysbiosis of the upper digestive tract — a harbinger of rheumatoid arthritis? Experimental and Clinical Gastroenterology. 2019;163(3): 10–15. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-10-15
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    1. Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia
    2. Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia
    3. Novosibirsk Regional Clinical Diagnostic Center, Novosibirsk, Russia
    4. First Moscow State Medical University named after I. M. Sechenov, Moscow, Russia
    5. Moscow Regional Research and Clinical Institute (“MONIKI”), Moscow, Russia

    Keywords: gastroesophageal reflux disease, Barrett’s esophagus, hiatal hernia, extraesophageal manifestations of gastroesophageal reflux disease

    Abstract: Over the years, Barrett’s esophagus doesn`t lose its relevance to clinicians and researchers. The problem is acute as the disease is considered as a precancerous condition associated with the risk of adenocarcinoma in the lower third of the esophagus. Knowledge of non-esophageal clinical “masks” of gastroesophageal reflux disease (GERD) and timely diagnosis is extremely relevant for Barrett’s esophagus patients with a high risk of its development as well as complex treatment and dynamic observation of these patients. The article describes a clinical case of a 10-year unsuccessful case of a 36-years old man with GERD complicated by Barrett’s esophagus. Different specialists who observed the patient didn`t evaluate patient’s cardiac and otorhinolaryngological complaints as extra-esophageal “masks” of GERD, although there was a bright clinical picture of the disease, repeated instrumental examination, including esophagogastroduodenoscopy. courses of antioxidants, metabolic drugs, vegetocorrectors, local treatment of laryngitis, intraperitoneal instillations were unjustifiably prescribed. This practice underlines the timeless relevance of assessing anamnestic data, clarifying the presence of comorbid conditions to ensure an adequate personalized drug approach.

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    Full text is published :
    Tsygankova O. V., Latyntseva L. D., Batluk T. I., Gaskina T. K., Starichkov A. A., Bueverov A. O. Gastroesophageal reflux disease with non-esophageal manifestations, the formation of Barrett’s esophagus on the background of a hiatal hernia. Experimental and Clinical Gastroenterology. 2019;163(3): 16–23. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-16-23
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    1. The Loginov Moscow Clinical Scientifi c Center, 111123 shosse Enthuziastov 86, Moscow, Russia

    Keywords: chronic pancreatitis, pancreatic cancer, fibronectin, median of enhancement gradient

    Abstract: Aim. To assess significance of serum fibronectin and new approaches of computed tomography for pancreatic cancer and chronic pancreatitis differential diagnosis. Material and methods. Data of 49 patients with pancreatic lesions who underwent multislice computed tomography (MSCT) with intravenous contrast enhancement and serum fibronectin (FN) evaluation in 2018 were analyzed. There were 29 (59.2%) males and 20 (40.8%) female patients, mean age 51.9+13.9 (30-82). All patients divided in 3 groups: 1 - with pancreatic ductal adenocarcinoma (PDAC) - 17 p., 34.6%, 2 - chronic pancreatitis with previous pancreonecrosis (CPPN) - 16 p., 32.7%, 3 - chronic calcifying pancreatitis (CCP) - 16 p., 32.7%. All cases of PDAC were pathologically proved. We calculated median of enhancement gradient between region of interest and intact parenchyma (Мgrad) based on MSCT results. Pearson’s correlation coefficient (rp) was calculated for correlation assessment. Results. We assessed mean Мgrad and mean serum FN rate in all three groups: PDAC - 28.1+2.6, р=0.0001, CPPN - 14.9+2.4, р=0.07, CCP - 13.3+0.7, р = 0.08 for Мgrad, and 239.8+30.1, p=0.8, 243.5+33.8, p=0.7, 227.2+34.3, p=0.8 for serum FN rate, respectively. There was statistically significant strong correlation of Мgrad in patients with PDAC (rp=0.63, p=0.0001). We revealed cut-off point of Мgrad value for PDAC that was 20 (p=0.001). There were no statistically significant correlations of serum FN rate in all groups (PDAC rp=0.04, p=0.8; CPPN rp=0.06, p=0.7; CCP rp= -0.03, p=0.8). Conclusion. Mgrad evaluation based on MSCT is an informative marker for differential diagnosis between PDAC and chronic pancreatitis, high rates of Мgrad positively correlate with PDAC existence. There was no correlation between serum FN rate and existence of PDAC, CPPN or CCP revealed.

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    Vinokurova L. V., Lesko K. A., Bordin D. S., Dubtsova E. A., Tyulyaeva E. Yu., Varvanina G. G. Research of new approaches of differential diagnosis of pancreatic lesions. Experimental and Clinical Gastroenterology. 2019;163(3): 24–30. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-24-30
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    1. FSBEI HE SUSMU MOH Russia, 454092, Russian Federation, Ural Federal District, Chelyabinsk region, Chelyabinsk city, Vorovskogo street, 64

    Keywords: chronic pancreatitis, Helicobacter pylori, gastrin, exocrine insuffi ciency

    Abstract: Purpose of the study. To assess the state of the acid-producing function of the stomach in patients with varying degrees of functional insufficiency of the pancreas in the presence of Helicobacter pylori-associated gastritis. Materials and methods: 77 patients with chronic pancreatitis and concomitant Helicobacter pylori-associated gastritis were examined. The control group consisted of 56 patients with chronic pancreatitis without Helicobacter pylori-associated gastritis. Diagnosis of chronic pancreatitis was based on anamnestic, clinical data, instrumental studies (MSCT). The exocrine function of the pancreas was assessed by the content of pancreatic elastase in the feces. Diagnosis of H. pylori infection was carried out by the morphological method, urease respiratory test 13C, by immunoblotting. All patients underwent endoscopic examination of the stomach. In some patients, the level of gastrin 17 in the blood was determined. Statistical processing was carried out using SPSS Statistic 17.0 application software packages. Results. Pain syndrome was significantly more frequently observed in H.pylori- positive patients with chronic pancreatitis (93.2%, p = 0.045), while more often epigastric pain was observed (30.7% versus 12.5% of the control group, p = 0.48). In patients with chronic pancreatitis with an intense pain syndrome, in 66.7% of cases, the combination of proteins p26, p19 and p17 with CagA H.pylori was detected. In patients with chronic pancreatitis with concomitant Helicobacter pylori-associated gastritis, the level of gastrin was outside the normal range in 57.1% of cases (control group - 18.2%, p = 0.048) and was below normal in 42.9% of patients. The average value of gastrin in patients of the studied group was lower (3.140 ± 0.802 pmol / l) than in the control group (4.833 ± 1.594 pmol / l, p = 0.045). In patients with exocrine pancreatic insufficiency, the level of gastrin was reduced / increased in 75% of cases (p = 0.014). In patients with severe chronic pancreatitis, gastrin levels were significantly more often not normal (p = 0.041). CagA VacA - positive strains were statistically significantly more frequently detected in patients with chronic alcoholic pancreatitis and correlated with the severity of the disease. Conclusion. Helicobacter pylori infection contributes to a variety of clinical manifestations in patients with chronic pancreatitis. Helicobacter pylori - a positive status in patients with chronic pancreatitis is associated with more intense gastric acid-induced acid production in the stomach. The severity of morphological changes in chronic pancreatitis, as well as exocrine pancreatic insufficiency correlates with CagA- positive strains of Helicobacter pylori and fluctuations in gastrin levels in the digestive period.

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    Domracheva E. V., Sarsenbaevа A. S. Clinical and functional features of patients with chronic pancreatitis and related helicobacter pylori-associated gastritis. Experimental and Clinical Gastroenterology. 2019;163(3): 31–37. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-31-37
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    1. Donetsk National Medical University Ministry of Health of Ukraine, 84404, Donetsk region, Liman, Ukraine
    2. “Endotehnomed”, Dnepr, Ukraine

    Keywords: pancreas, chronic pancreatitis, histostructure

    Abstract: Aim - to study the morphological features of the pancreas in clinical and morphological forms of chronic pancreatitis. Materials and methods. Histological preparations of the pancreas were studied in 60 patients with various forms of chronic pancreatitis. Results. Scant inflammatory infiltration of the pancreatic parenchyma (represented by lymphocytes, plasma cells), atrophic and fibrotic changes, which were characterized by unidirection, were detected. The fibrosis was of two kinds - friable and dense fibrosis, that qualitative state of the connecting tissue at the different forms of chronic pancreatitis. Friable fibrosis has been revealed at patients for mild and moderate chronic pancreatitis and dense - for severe and complete fibrosis. Conclusion The morphological picture of fibrous changes of the pancreas does not depend on the form of the disease and is characterized by a mild degree of fibrosis in 6.6% of patients, moderate - in 20.0%, severe - 16.7%, full fibrosis - 56.7%.

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    Gubergrits N. B., Krylovа О. A., Opikhailo М. C. Features of the pancreatic histostructure in chronic pancreatitis. Experimental and Clinical Gastroenterology.2019;163(3): 38–42. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-38-42
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    1. Institute of Experimental Medicine, Almazov National Medical Research Centre, 197341, Saint Petersburg, Russian Federation
    2. Shevchenko Transnistria State University, 3300, Tiraspol, Moldova
    3. Institute of Physiology and Sanocreatology, MD-2028, Chisinau, Moldova
    4. Scientifi c Research Center “Probiocode SP”, 143026, Moscow, Russian Federation
    5. First Pavlov State Medical University of St. Petersburg, 197022, St. Petersburg, Russia

    Keywords: antibiotics, isolated intestinal loop, absorption, monosaccharides, isolated heart, infarct size

    Abstract: Aim: we aimed to study the effect of the mixture of three broad-spectrum antimicrobials (amoxicillin, metronidazole, clarithromycin, AMC) on monosaccharide absorption in the isolated intestinal loop and on myocardial tolerance to ischemia-reperfusion injury (IRI). Materials and Methods: experiments were performed on adult male Wistar rats housed in conventional area. Glucose and fructose absorption was studied in the model of in situ isolated intestinal loop according to Thiry-Vella after administration of AMC into the intestinal lumen. Isolated heart studies were done using modified Landendorff setup after oral treatment of the animals with AMC. Results: AMC significantly inhibited glucose absorption in the isolated intestinal loop, mainly due to pronounced reduction of active, sodium-dependent glucose cotransporter 1-mediated transport. AMC also caused inhibition of fructose absorption. The animals treated with AMC showed decreased systolic pressure in the left ventricle up to 20% upon reperfusion, decreased pressure in the left ventricle during global ischemia (by 33-500%), increased coronary flow by 28-82%, and also insignificant trend to greater infarct size. Conclusion: AMC-induced inhibition of glucose and fructose absorption provides evidence for the existence of rapid changes in nutrient absorption, mainly due to inhibition of active transport. AMC treatment also resulted in deterioration of morphological and functional parameters of the isolated heart. The data obtained warrant further studies on the antibiotic-induced associated changes in enterocytes and cardiomyocytes.

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    Burovenko I. Yu., Borshchev Yu. Yu., Minasian S. M., Protsak E. S., Sheptitskii V. A., Galagudza M. M. The study of absorption of monosaccharides in the isolated intestine and resistance of the myocardium to ischemia-reperfusion in rats after administration of antimicrobial agents. Experimental and Clinical Gastroenterology. 2019;163(3): 43–50. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-43-50
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    1. “Gamaleya National Research Centre for Microbiology and Immunology”, Ministry of Public Health of Russian Federation, Moscow, Russia
    2. “Kinetika Co., Ltd”, Moscow, Russia
    3. “Sechenov The First Moscow Medical University”, Ministry of Public Health of Russian Federation, Moscow, Russia
    4. “Moscow Institute of Physics and Technology (State Research University)”, Moscow, Russia

    Keywords: Helicobacter pylori, cold plasma, bactericidal effect

    Abstract: Medicinal liver damage (LPP) is one of the main undesirable effects of pharmacotherapy. The emergence of new drugs on the pharmaceutical market, an increase in the number of LPP caused by herbal preparations and biologically active additives, as well as the expansion of the market for immunobiological drugs, make drugs the most important etiological factors for liver damage. For timely diagnosis of LPP, it is necessary to take into account the totality of risk factors, among which, in recent years, significant attention has been paid to biomarkers. The choice of tactics for the management of a patient with LPP is determined by the nature and severity of the disease, the characteristics of the use of a potentially hepatotoxic drug and the individual characteristics of the patient. The appointment of drugs with high hepatotoxic potential sometimes requires a preventive prescription of pathogenetic agents. When using drugs with low hepatotoxic potential, individual monitoring of biochemical parameters is recommended.

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    Zhukhovitsky V. G., Kazakova M. V., Sysolyatina E. V., Loleit R. A., Lavrikova A. Ya., Sofronov A. V., Ermolaeva S. A. Bactericidal eff ect of low-temperature plasma against Helicobacter pylori in vitro. Experimental and Clinical Gastroenterology. 2019;163(3): 51–57. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-51-57
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    1. Moscow Clinical Scientifi c practical Center named after A. S. Loginov, Department of health, city of Moscow, 111123, Moscow, Russia
    2. “Research Center of Neurology”, Moscow, Russia
    3. FGBOU VPO “Mordovian state University. N. P. Ogarev”, Saransk, Republic of Mordovia, Russia

    Keywords: antiplatelet agents, aspirin, gastrointestinal ulcer, antioxidants, carnosine, rats

    Abstract: Antiplatelet drugs are widely used for the prevention and treatment of vascular diseases of the heart and brain. The most popular drugs are non-steroidal anti-inflammatory drugs, the first place among which still belongs to acetylsalicylic acid (aspirin) and its derivatives. However, along with high clinical efficacy according to target parameters, these drugs have side effects that lead to damage to the mucous membrane of the gastrointestinal tract (GI). In order to eliminate the effects of damage to the gastrointestinal tract with the use of antiplatelet drugs, based on salicylic acid, using a natural dipeptide carnosine, a new compound was synthesized - salicyl-carnosine, which has an antiplatelet effect. A comparative study on carnosine, acetylsalicylic acid and salicyl-carnosine for the healing of ulcerative defect was carried out on the model of acetate gastric ulcer by Okabe. It was shown that salicyl-carnosine was more effective than carnosine both at the stage of ulcer formation (1-5 s) and at the stage of healing (5-10 s). Acetylsalicylic acid in the used model of gastric ulcer not only did not prevent the development of gastric ulcer, but also complicated the healing processes. The results indicate the possible prospects for the use of salicyl-carnosine as an antiplatelet drug in vascular pathologies (cardiac, Central nervous system, etc.), to avoid side effects associated with damage to the gastrointestinal tract, inherent in aspirin and other NSAIDs. Non-steroidal anti-inflammatory drugs.

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    Trubitsyna I. E., Stvolinsky S. L., Kulikova O. I., Fedorova T. N., Tarasova T. B., Efremov L. I., Mikhailova S. F., Varvanina G. G. Protective effect of the new compound — salicyl-carnosine — on the formation of chronic acetate gastric ulcer in rats. Experimental and Clinical Gastroenterology. 2019;163(3):58–64. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-58-64
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    1. Republican Specialized Scientifi c and Practical Medical of Pediatrics, 100174 Tashkent, Uzbetkistan
    2. Center of Advanced Technologies under the Ministry of Innovation Development of the Republic of Uzbekistan, 100174 Tashkent, Uzbetkistan

    Keywords: Chronic enteral insuffi ency, oxidative phosphorylation, mytochondria, phytoecdysteroid, ecdysten

    Abstract: Aim.To study the state of oxidative phosphorylation in a model of chronic enteral insufficiency in the growing rats and to assess the effectiveness of ecdystene in their correction. Materials and methods. Laboratory white mongrel rats were used in the experiments. The animals were divided into 3 groups. 1 group - healthy animals (control). Group 2 - animals on a diet poor in protein (chronic malnutrition), group 3 - animals that received as a corrective drug ecdysthene. Mitochondria were isolated from the liver of 40-day-old rats by differential centrifugation. The parameters of oxidative phosphorylation, respiration rate of isolated mitochondria in the metabolic state V4 and V3, as well as the values of respiratory control and ADP / O were determined. Results. Treatment of rats with protein deficiency for 10 days with the drug ecdystene resulted in a significant increase in the body weight of the rats - an average of 45.5% - and by the 10th day of treatment this value was 71% of the values in the control group (P <0.01). In the group of animals that were on a diet poor in proteins, the oxidative phosphorylation parameters were significantly reduced. The rate of oxygen consumption by the mitochondrial suspension in the functional state of V3 and V4 in sick animals was almost half that in control animals. Respiratory control, in the group of sick animals was reduced by 20%. The ratio of ADP / O was also reduced and was 2.5 vs 2.8 in the control group. When using a corrective ecdystene preparation as a quality, the V3 state was 93.72, V4 was 15.62, and Vdnf was 109.34 ng at O / min / mg protein (P <0.001). The value of the respiratory control was also close to the control and was 6, and the ratio of ADP / O even slightly exceeded the control value and was 3.03 (P <0.05). Сonclusion. We detected a pronounced disconnection of the respiratory chain in the mitochondrial suspension when the animals were kept on a diet poor in proteins and also had a bright corrective effect in the ecdystene. The therapeutic effect of ecdysten revealed its pronounced ability to correct manifestations of chronic enteric insufficiency in growing rats.

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    Kamilova А. Т., Dustmuhamedova D. H., Levickaya Yu. V. Disorders of oxidative phosphorylationin the model of chronic enteral insufficiency and their correction. Experimental and Clinical Gastroenterology. 2019;163(3): 65–69. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-65-69
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    1. Federal State Budgetary Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Healthcare of the Russian Federation, 344022, Rostov-on-Don, Russia
    2. Сlinical diagnostic center “Zdorovie”, 344011, Rostov-on-Don, Russia

    Keywords: Chronic enteral insuffi ency, oxidative phosphorylation, mytochondria, phytoecdysteroid, ecdysten

    Abstract: Radiofrequency ablation can achieve a significant reduction of simple liver cysts. The aim of the study was to investigate the effects of RFA in various regimes on the wall of the liver cyst and adjacent tissue, and to define optimal exposure parameters. Materials and methods. An experimental study was performed by constructing of imitational models of a simple liver cyst (group № 1), a biliary cyst (group № 2), and a cyst with high electrical conductivity content (10% NaCl solution) -group № 3. The models were exposed to RFA in the range of temperatures from 50 to 92 °C with duration from 1 to 5 minutes. Then, the postablation changes of the preparations were assessed using histological examination. Results. In all groups, when heated, there was a lag of the temperature of the cystic medium compared with the temperature of the electrode. For models of group № 1, № 2, and № 3, the difference was 19.6 °C, 8.75 °C, and 3.8 °C, respectively. Coagulation necrosis was found in all preparations and was most pronounced in the surface layers of the tissue contacted with the heated medium. The absence of destruction of the adjacent liver tissue in group № 1 was found for RFA in regimes using 61-63 °C for 2 minutes; in group 2 - using 65-75 °C for 3 minutes; in group 3 - using 85 °C (for 2 minutes) or 53-55 °C (for 5 minutes). Conclusion. The destruction of all epithelial cells is achievable with RFA; however, the thermal range between total ablation and the thermal injury of adjacent healthy tissue is narrow. The introduction of 10% NaCl solution can increase the area of necrosis and makes possibility to control the temperature of the cyst. Achieving mild ablation with shallow penetration of necrosis is influenced by the volume and electrical conductivity of the cystic content, adequate control of the temperature in the cystic cavity, and dosed use of RFA power and exposure time.

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    Cherkasov M. F., Aboyan I. A., Aboyan M. E., Roshak B. V., Lemeshko S. I., Malikov L. L., Khanamirova L. Z., Buharbaev R. M., Melikova S. G. Reducing the size of the experimental liver brush using radiofrequency ablation. Experimental and Clinical Gastroenterology. 2019;163(3): 70–76. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-70-76
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    1. Irkutsk Scientifi c Center of the Siberian Branch of the Russian Academy of Sciences (664033, Irkutsk, Russia)
    2. Irkutsk Scientifi c Center for Surgery and Traumatology (664003, Irkutsk, Russia)
    3. Irkutsk Regional Clinical Hospital (664049, Irkutsk, Russia)

    Keywords: ---

    Abstract: ------.

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    Lepekhova S. A., Goldberg O. A., Prokop’ev M. V., Kurgansky I. S., Kireeva V. V., Inozemcev P. O., Apartsin K. A. Effect of toxic liver damage on structural changes in mitochondria and intracellular organelles. Experimental and Clinical Gastroenterology. 2019;163(3): 77–80. (In Russ.) DOI: 10.31146/1682- 8658-ecg-163-3-77-80
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    1. GBUZ Moscow Clinical Research Center named after A. S. Loginov DZM, Moscow, Russia

    Keywords: fatty liver disease, diabetes mellitus, correction, receptors, monoclonal antibodies

    Abstract: Non-alcoholic fatty liver disease (NAFLD), according to forecasts of the World Health Organization, by 2020 it will take the 1st place among all liver diseases., Liver transplantation in patients with cirrhosis in the outcome of NAFLD already takes 2nd place after liver cirrhosis of viral etiology. In patients with NAFLD, mortality in the 1st month after surgery significantly exceeds this indicator in case of liver cirrhosis of a different etiology, and there is an increased risk of other complications of liver transplantation, such as sepsis, transplant rejection and cardiovascular pathology. Specific diagnostic criteria and standard therapy of NAFLD, in practice, does not exist, most likely the diagnosis of NAFLD - “diagnosis of exclusion.” Despite the high prevalence of NAFLD to date, the problem of its effective therapy has not been solved. None of the drugs used in the treatment of NAFLD has a high evidence base. Correction of body weight, changes in food addiction, physical activity are the most effective measures preventing the development of NAFLD and elimination of those negative metabolic processes that are predictors of development of severe forms of type 2 diabetes and high risks of cardiovascular diseases..

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    Zvenigorodskaya L. A., Khomeriki S. G., Lychkova A. E. Promising methods for the treatment of dyslipidemia in patients with NAFLD. Experimental and Clinical Gastroenterology. 2019;163(3): 81–88. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-81-88
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    1. I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
    2. Moscow Regional Research and Clinical Institute (“MONIKI”), Moscow, Russia

    Keywords: drug damage to the liver, epidemiology, risk factors, treatment

    Abstract: Medicinal liver damage (LPP) is one of the main undesirable effects of pharmacotherapy. The emergence of new drugs on the pharmaceutical market, an increase in the number of LPP caused by herbal preparations and biologically active additives, as well as the expansion of the market for immunobiological drugs, make drugs the most important etiological factors for liver damage. For timely diagnosis of LPP, it is necessary to take into account the totality of risk factors, among which, in recent years, significant attention has been paid to biomarkers. The choice of tactics for the management of a patient with LPP is determined by the nature and severity of the disease, the characteristics of the use of a potentially hepatotoxic drug and the individual characteristics of the patient. The appointment of drugs with high hepatotoxic potential sometimes requires a preventive prescription of pathogenetic agents. When using drugs with low hepatotoxic potential, individual monitoring of biochemical parameters is recommended.

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    Bueverov A. O., Bueverova E. L. The evolution of ideas about medicinal liver damage. Experimental and Clinical Gastroenterology. 2019;163(3):89–96. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-89-96
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    1. Saratov state medical university of V. I. Razumovsky of the Russian Ministry of Health, Saratov, Russia
    2. Branch of private institution of the educational organization of the higher education “The medical university “Reaviz”, Saratov, Russia

    Keywords: sharp cholecystitis. mechanical jaundice, system infl ammatory answer (SIRS)

    Abstract: The modern literary review the devoted question of sharp cholecystitis and mechanical jaundice is presented in article, it is established that now weight of a condition of the patient with sharp cholecystitis and mechanical jaundice is still estimated on kliniko-biochemical weight of an ikterus and the progressing liver failure. Other syndromes are considered insufficiently. It is especially important to reflect a syndrome of the system inflammatory answer (SIRS) which reflects weight of the developing inflammatory process in a biliarny system.

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    Full text is published :
    Fedorov V. E., Zaharova N. B., Logvina O. A., Maslyakov V. V. Assessment of severity of the patient at sharp cholecystitis and mechanical jaundice in the light of national clinical recommendations (the review of literature). Experimental and Clinical Gastroenterology. 2019;163(3): 97–104. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-97-104
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    1. EI of HE “The Surgut State University”, Surgut, Russia
    2. Surgut District Clinical Hospital, Surgut, Russia
    3. FSEBI of HE “The Ulianov Chuvash State University”, Cheboksary, Russia
    4. Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russia

    Keywords: chronic viral hepatitis, protein metabolism, liver fi brosis

    Abstract: Purpose. To analysis of Russian and foreign literature about epidemiology, etiology and pathogenesis of chronic viral hepatitis B and C, including the factors that are likely to have effect on the progression of liver fibrosis, such as, condition of protein metabolism. Materials and methods. The literature data about this subject in the volume 58 sources of literature, 22 - Russian works and foreign - 36 was studied. Results and discussion. The most frequent factors that are likely to have effect on the progression of liver fibrosis, such as, etiology of chronic viral hepatitis B and C, combined viral pathology, features of the macrooganism, duration of infection, effect of alcohol and smoking were detected. The questions of the condition protein metabolism of chronic viral hepatitis B and C has been considered. Conclusion. The obtained data is different, because impact of the condition protein metabolism and other factors are important for learning and use in clinical practice with this pathology.

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    Full text is published :
    Tarasova L. V., Ariamkina O. L., Volkova T. V., Busalayeva E. I., Sosnovskaia E. V. Protein metabolic disorders in chronic viral hepatitis. Experimental and Clinical Gastroenterology. 2019;163(3): 105–112. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-105-112
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    1. N. N. Blokhin Russian Cancer Research Center, Moscow, Russia
    2. I. M. Sechenov First Moscow State Medical University, Moscow, Russia

    Keywords: ovarian cancer, stomach metastasis, immunocytochemistry, immunohistochemistry

    Abstract: Stomach metastases from different types of malignant tumors are extremely rare. Common sources of secondary gastric involvement are breast and lung cancer, neoplasms of unknown primary site, malignant melanoma (2). Ovarian carcinomas average 0,013-1,6% of all gastric metastases (1). Ulceration is one of the important features of metastatic stomach lesions (3). We herein present the case of ovarian carcinoma metastasis to the stomach 13 years after panhysterectomy. Secondary gastric involvement was diagnosed during esophagogastroduodenoscopy and biopsy of posterior gastric wall infiltrated mucosa. The result was additionally confirmed immunohistochemically while analyzing biopsy specimens of visceral peritoneum. In conclusion, although gastric metastases from ovarian carcinoma is exceptionally rare, clinicians should nevertheless be aware that in patient with gastric tumor and a history of ovarian cancer, gastric lesions may be metastases from the ovarian cancer.

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      3. Kang W, Kim C. Primary epithelial ovarian carcinoma with gastric metastasis mimic gastrointestinal stromal tumor. Cancer Research and Treatment. 2008; 40(2): 93-96.
      4. Obeidat F, Mismar A, Shomaf M, Yousef M, Fram K. Gastric perforation secondary to metastasis from ovarion cancer: case report. International Journal of Surgery Case Reports. 2013; 4(6): 541-543.
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      9. Khalikova L. V. The greater omentum in women with ovarian cancer. Creative surgery and oncology. 2013;(4):80-83. (In Russ.)

    Full text is published :
    Bogush E. A., Malikhova O. A., Belyaeva T. V., Kirsanov V. Yu., Polikarpova S. B., Vysotskaya I. V., Ponomarev V. E. Metastatic lesion of the stomach in advanced ovarian cancer (case report). Experimental and Clinical Gastroenterology. 2019;163(3): 113–115. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-113-115.
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    1. The Loginov Moscow Clinical Scientific Center is State Institution funded by Moscow Health Department (The Loginov MCSC MHD) (Moscow, Russia)

    Keywords: hepatocerebral dystrophy (Wilson-Konovalov disease), disorders of copper metabolism, ceruloplasmin, hepatic form, abdominal form, neurological disorders, diagnosis, D-penicillamine, zincteral, liver transplantation

    Abstract: Wilson-Konovalov disease (WKD) is one of the most difficult to diagnose liver disease due to the long latent course in the early stages and the large polymorphism of symptoms in the advanced stage of the disease. The main signs of WKD are liver diseases, neuropsychiatric disorders, Kayser-Fleischer ring, acute episodes of hemolysis, often in combination with acute liver failure. The diagnosis is especially difficult in children and adults with active forms of liver disease. Timely diagnosis is an important medical and social problem, since early pathogenetic therapy improves the quality of life and social adaptation of patients. The article deals with the pathogenesis of BVK, the clinical and morphological features of the variants of the course of the disease: fulminant hepatic failure, chronic hepatitis and latent variant with the development of liver cirrhosis. An abdominal form with early development of edema and ascitic syndrome on the background of a violation of the synthetic function of the liver was identified. A detailed description of the role of a violation of copper metabolism To overcome the diagnostic problem, several clinical and laboratory signs are evaluated, as well as genetic testing in a point system; this assessment allows you to calculate the likely and very likely diagnosis. The tactics of drug therapy and the possibility of optimizing it are considered, the advantage of liver transplantation is evaluated. Two clinical observations of Wilson-Konovalov’s disease are presented, demonstrating the capabilities of various diagnostic methods (1st observation) and features of the course of the hepatic form of the disease (2nd observation).

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      2. European Association for Study of Liver; EASL Clinical Practice Guidelines: Wilson’s disease. J Hepatol. 2012;56:671-85.
      3. Disorders of copper metabolism (Wilson`s Disease) in children. Clinical guidelines. - 2016-36c.
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      6. Zischka H., Einer C. Mitochondrial copper homeostasis and its derailment in Wilson disease. The International Journal of Biochemistry & Cell Biology. Volume 102, September 2018, Pages 71-75.
      7. Podymova S. D. Liver Diseases: Manual. - The 5thed., revisead and srepplemented. - Moscow: Medical Informational Agency, 2018. - 984 p.
      8. Podymova S. D., Yasnova N. N. Liver and hepatocerebral dystrophy. Rubbed archive 1983; 10: 9-13
      9. Shimamura, Y., Maeda, T., Gocho, Y. et al. CEN Case Rep (2018). Immunoglobulin A nephropathy secondary to Wilson’s disease: a case report and literature review
      10. Di Stefano V, Lionetti E, Rotolo N, La Rosa M, Leonardi S. Hypercalciuria and nephrocalcinosis as early feature of wilson disease onset: description of a pediatric case and literature review. Hepat Mon. 2012;12(8): e6233
      11. Ullah, A.K.M.A., Maksud, M.A., Khan, S.R. et al. Biol Trace Elem Res (2018). Morning (First) Urine Copper Concentration: a New Approach for the Diagnosis of Wilson’s Disease
      12. Balashova M. S., Solov`eva O.V., Fastovets S. V., Tulusanovskaya I. G., Filimonov M. I., Bayazutdinova G. M., Zhuchenko N. A., Ignatova T. M., Asanov A. Y. The clinical value of ATP7B sequencing in the diagnosis of Wilson`s disease. Medical Genetics. 2016;15(7):14-16.
      13. Ferenci P. Handbch Clin Neurol. 2017;142:171-180. doi: 10.1016/B978-0-444-63625-6.00014-8. Diagnosis of Wilson disease.
      14. Golovanova E. V., Lazebnik L. B., Konev Yu.V., Shaposhnikova N. A. Wilson’s disease (hepatolenticular degeneration, dystrophia hepatocerebralis) diagnosis, treatment and dispensary observation. Experimental and Clinical Gastroenterology. 2015; 119 (7): 108-111.
      15. Roberts Eve A., Socha Piotr Wilson disease in children.

    Full text is published :
    Podymova S. D., Vinnitskaia E. V. Liver and hepatocerebral dystrophy. Experimental and Clinical Gastroenterology. 2019;163(3): 116–124. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-116-124.
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    1. Saratov State Medical University named after V. I. Razumovsky, Saratov, Russia


    Abstract: On February 14-15, 2019, in Saratov, the next visiting plenary meeting of the NOGR “Microbiota, Microbiomes and Chronic Infections in Gastroenterology” was held. Problems of polymorbid patients ”, which was held as part of the 50th Anniversary Conference of the Russian Scientific Medical Society of Therapists. The plenum was attended by over 300 doctors of various specialties: gastroenterologists, therapists, endoscopists, family doctors, TB doctors. The plenary session was opened by the President of the NOGR Dr. med. Professor L. B. Lazebnik (Moscow), who at the symposium "Gastroenterological Aspects of Tuberculosis" in his program report presented the draft international clinical recommendations "Digestive tuberculosis."…….


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    Kozlova I. V. Plenum of the GSSR on February 14–15, 2019, Saratov. Experimental and Clinical Gastroenterology. 2019;163(3): 125–127. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-125-127
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    1. Moscow state medical and dental University named after A. I. Evdokimov (Moscow, Russia)


    Abstract: Vladimir Ilyich Simanenkov was born in Petrozavodsk, the capital of the Karelian Autonomous Soviet Socialist Republic. Father - Ilya Konstantinovich - front-line poet, worked as an editor of a local garrison newspaper. Mom - Anna Zakharovna, a teacher, raised three sons. In his school years, Vladimir spent all his free time in the reading room of the library, for his academic excellence and active life position he was awarded a trip to Artek. After graduating from school in 1966, he entered the medical faculty of Petrozavodsk State University, combining his studies with classes in the SSS on therapy and emergency work and in the department of anesthesiology and intensive care of the republican hospital. After graduating from the university in 1972, the young doctor began working as a therapist in the Podporozhsky CRH. In 1975 he was sent to refresher courses at LenGIDUV at the Department of Therapy, which was led by prof. Yu. M. Gubachev, pioneer of domestic psychosomatics. This trip played a decisive role in the life of Vladimir Ilyich. He became interested in the problems of psychosomatic medicine, and in the same year 1975 entered the clinical internship at this department and began scientific work, which in 1980 ended with the defense of his dissertation on the topic “Comparative psychosomatic characteristics of peptic ulcer and coronary heart disease”. In 1979, Vladimir Ilyich passed the competition for the position of assistant to the Department of Therapy No. 2 with a course of psychosomatics LenGIDUV and since then has been working here for 40 years. The scientific and pedagogical career developed rapidly and in 1991 V. I. Simanenkov defended his doctoral dissertation “Psychosomatic aspects of pre-ulcerated conditions and peptic ulcer disease”, and a year later he was awarded the title of professor. Since 1991, Vladimir Ilyich headed the Department of Therapy No. 2, which subsequently - on his initiative - began to prepare not only therapists, but also clinical pharmacologists for practical activities, and now it is called the Department of Therapy and Clinical Pharmacology of the North-Western Medical University named after I.I. Mechnikov. Under his leadership, many candidate and doctoral dissertations were defended. Professor V.I.Simanenkov is the author of more than 400 scientific papers on topical issues of internal medicine and psychosomatics. For several years V.I.Simanenkov was the chief therapist of the Health Committee of the Government of St. Petersburg, paying great attention to improving the quality of therapeutic care for the city population and increasing the level of medical knowledge of therapists. For nearly twenty years in St. Petersburg with the active participation of Prof. V. I. Simanenkov, Deputy Chairman of the St. Petersburg Society of Therapists named after S.P. Botkin, the Congress of Therapists of St. Petersburg and the Northwestern Federal District is held, which causes the continued interest of doctors of various specialties. In February 2019, the annual final Conference of the Association of Therapists of St. Petersburg (founded in 2002) was held again, the President of which has been Professor V.I.Simanenkov for many years. Over the past few years, V.I.Simanenkov has also been the head of the Northwestern branch of the Russian Gastroenterological Association (RGA). On the initiative of Vladimir Ilyich, to unite specialists and increase their level of knowledge, congresses “Psychosomatic Medicine” have been held annually since 2006, and since 2015 the Neva Congresses of Gastroenterologists and Therapists “Realities and New Horizons in Gastroenterology and Hepatology”. By decree of the President of the Russian Federation of June 17, 2000, No. 1106, prof. V. I. Simanenkov was awarded the honorary title “Honored Worker of Higher School of the Russian Federation”. V.I.Simanenkov has a medical family, his wife Marina Sergeevna is also a doctor. Daughter Anna, continuing the dynasty, also chose a medical specialty, graduating from the First St. Petersburg State Medical University. Academician I.P. Pavlov. The work as the head of the department, the management of the Association of Physicians of St. Petersburg and the Northwestern branch of the RSA require a lot of effort, numerous meetings, speeches at congresses and conferences, both in Russia and abroad. Therefore, Vladimir Ilyich likes to spend his holidays not in fashionable resorts, but in the country, in his native Karelia. Every year, with his own hands in the country, he personally makes something new: a porch, a bathhouse, and country furniture. And this talented and multifaceted person with unfading energy is fascinated by fishing and mushroom forests! The Scientific Society of Gastroenterologists of Russia (NOGR), the Editorial Board and the Editorial Board of the journal Experimental and Clinical Gastroenterology wish Vladimir Ilyich many years of life, filled with fruitful work for the benefit of national health care!

     Full text is published :

    Lazebnik L. B. Vladimir I. Simanenkov — 70! Experimental and Clinical Gastroenterology. 2019;163(3): 128–129. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-128-129
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    1. Moscow state medical and dental University named after A. I. Evdokimov (Moscow, Russia)


    Abstract: In February 2019, the 85th year of his life, the famous Russian gastroenterologist, Honored Doctor of the Russian Federation, member of the editorial board of the journal Experimental and Clinical Gastroenterology, member of the board of the Moscow Scientific Society of Therapists, member of the board of the Russian Gastroenterological Association, professor of the Department of Gastroenterology of the Institute for Advanced Medical Studies of the Ministry Defense of the Russian Federation, Doctor of Medical Sciences Andrei Viktorovich Kalinin. At the end of the First Moscow Medical Institute in 1959, he was drafted into the Soviet Army. After three years of service, the rank of senior lieutenant of the medical service A.V. Kalinin was sent to the Main Military Clinical Hospital named after N. N. Burdenko, in which he worked for almost 30 years, being first a doctor, from 1969 - senior resident of the gastroenterological department, and from 1976 to 1988 - the head of the department. In 1972, Andrei Viktorovich successfully defended his PhD, and in 1988, a doctoral dissertation on symptomatic duodenal ulcers. In 1988, A. V. Kalinin was appointed deputy head of the Department of Therapy of the Military Medical Faculty at the Russian Medical Academy of Postgraduate Education, where he successfully engaged in pedagogical and scientific activities. In 1991, he was awarded the academic title of professor. In 1995, A.V. Kalinin was dismissed from the Armed Forces and was elected head of the department of gastroenterology at the State Institute for Advanced Medical Studies of the Ministry of Defense of the Russian Federation. As the head of the department, A. V. Kalinin always maintained a friendly atmosphere in the team, encouraged initiative, and stimulated the scientific interests of employees. He himself is the author of more than 250 printed works, 7 monographs and 4 manuals, including a manual for doctors “Gastroenterology and Hepatology: Diagnosis and Treatment”. In 2008, in connection with the reorganization measures, Andrey Viktorovich moved to the post of professor of the department. In the hearts of colleagues, Andrei Viktorovich will forever remain a sincere, kind, intelligent, open and interesting person, an erudite and a brilliant storyteller, a specialist who is ready to share his medical and life experience. Few people know that the doctor of medical sciences A. V. Kalinin is the author of the published watercolor illustrations for M. A. Bulgakov’s novel “The Master and Margarita” and the magnificent essay “Notes of the Old Muscovite”. May he bless you ... Presidium of the Scientific Society of Gastroenterologists of Russia Editorial board and editorial board of the journal Experimental and Clinical Gastroenterology.

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    Lazebnik L. B. In memory of Andrei V. Kalinin. Experimental and Clinical Gastroenterology. 2019;163(3): 130. (In Russ.) DOI: 10.31146/1682-8658-ecg-163-3-130.
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