ULTRASTRUCTURE OF PLASMA CELLS IN MUCOUS MEMBRANE OF DIGESTION ORGANS IN PATHOLOGY
Abstract
By the JEM-100S electron microscope, reactive changes in the plasma cells of the mucous membranes digestive organs (antrum stomach, duodenum, colon and ampulla of the rectum) were studied 30 patients with various pathologies (gastroduodenitis, irritable bowel syndrome, Crohn’s disease). At the ultrastructural level, the number of plasma cells in the colon of 6 patients with irritable bowel syndrome was counted and in 3 patients without signs of pathology in all parts of the colon (control). As a result of the study, the following are shown for the first time: ultrastructural changes in plasmacyttes during their functional activity associated with the production of immunoglobulins (antibodies) in response to the effect of antigens; Two ways to separation immunoglobulin complexes from plasma cells; The structure of immunoglobulin complexes freely located in the loose connective tissue of the proper mucous plate. All the patients examined had an increase in the content of active plasmacyttes. The reliable data on an increase in the amount of plasmacytes in the colon mucosa with irritable bowel syndrome have been obta ined.
About the Authors
V. F. Ivanova
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
S. V. Kostyukevich
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
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Review
For citations:
Ivanova V.F., Kostyukevich S.V. ULTRASTRUCTURE OF PLASMA CELLS IN MUCOUS MEMBRANE OF DIGESTION ORGANS IN PATHOLOGY. Experimental and Clinical Gastroenterology. 2017;(7):101-106. (In Russ.)
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