LABORATORY AND EXPERIMENTAL STUDY OF THE COMPLEX PROBIOTIC PREPARATION “BIFILACT-BILS” IN CAPSULATED FORM
Abstract
The composition and technology of complex probiotic in hard gelatin capsules was developed in Perm Branch «Biomed» of «Microgen» State Company. The preparation contains three production strains: Lactobacillus plantarum 8P-A3, L. acidophilus K3Ш24 and Bifidobacterium bifidum 1. Laboratory and experimental (preclinical) study of the probiotic included investigation of the antagonistic activity, “acute” and “chronic” toxicity, the effect of the preparation on histology and hematology of laboratory animals. The results of these studies suggested of the probiotic had high inhibitory activity against pathogenic microflora when compared with probiotic monopreparations and had no toxic effects on laboratory animals.
About the Authors
V. A. Neschislyaev
Federal State Unitary Company “Microgen”
Russian Federation
Russian Federation
M. G. Stolbova
Federal State Unitary Company “Microgen”
Russian Federation
Russian Federation
P. A. Mokin
Federal State Unitary Company “Microgen”
Russian Federation
Russian Federation
E. V. Orlova
Federal State Unitary Company “Microgen”
Russian Federation
Russian Federation
A. E. Ershov
Federal State Unitary Company “Microgen”
Russian Federation
Russian Federation
References
1. МУК 4.2. 2602-10. Методы контроля. Биологические и микробиологические факторы. Система предрегистрационного доклинического изучения безопасности препаратов. Отбор, проверка и хранение производственных штаммов, используемых для производства пробиотиков / Под ред. Н. В. Медуницына и др. - Москва. - 2008. - 78 с.
2. Методические указания по изучению общетоксического действия фармакологических веществ / сост. Е. В. Арзамасцев, Т. А. Гуськова, И. В. Березовская и др. - М. - 14 с.
3. Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / Под ред. члена-корр. РАМН, проф. Р. У. Хабриева. - Москва. - 2005. - 14 с.
Review
For citations:
Neschislyaev V.A., Stolbova M.G., Mokin P.A., Orlova E.V., Ershov A.E. LABORATORY AND EXPERIMENTAL STUDY OF THE COMPLEX PROBIOTIC PREPARATION “BIFILACT-BILS” IN CAPSULATED FORM. Experimental and Clinical Gastroenterology. 2016;(3):20-23. (In Russ.)
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